STIM1 and systemic lupus erythematosus: Impaired negative selection may also contribute to autoimmunity, though the normal Vβ repertoire of TCRαβ+ T cells in patients with STIM1 mutations suggests the absence of major defects in the induction of central tolerance.109,110 The recently reported regulatory function of STIM1 in controlling type I interferon responses111 could also be relevant in the pathogenesis of autoimmunity, at least in STIM1-deficient patients, and is consistent with the SLE-like autoantibody profile detected in these patients.105