CD3G and hyperinsulinemic hypoglycemia, familial, 4: Finally, autosomal-recessive CD3γ deficiency results in variable immunodeficiency, more commonly manifesting with hypogammaglobulinemia and recurrent respiratory tract infections.124,125 So far, all ten reported patients with CD3γ deficiency displayed autoimmune disease, most commonly manifesting as hypothyroidism and autoimmune cytopenias.