Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED, also known as autoimmune polyglandular syndrome type 1) is a rare multiorgan autoimmune disease caused by biallelic loss-of-function mutations in the gene encoding the autoimmune regulator (AIRE).24,25 AIRE is a transcription regulator orchestrating the expression of tissue-specific antigens (TSAs) by mTECs. The gene discussed is AIRE; the disease is autoimmune disease.