In addition, patients with NFKB2 mutations display reduced Treg counts.36,37 This, together with the fact that mice with conditional deletion of nfkb2 in Tregs develop lethal autoimmunity due to the impaired suppressive function of Tregs,38 suggests an additional Treg defect, which may be relevant in the pathogenesis of autoimmunity in NF-κB2 insufficiency. The gene discussed is NFKB2; the disease is Autoimmunity.