An explanation for this is the high frequency of repetitive sequence elements within and around DOCK8. In addition to infectious manifestations, including candidiasis, recurrent respiratory tract infections, and persistent cutaneous viral infections, DOCK8 deficiency has been associated with immune dysregulation manifesting as autoimmunity and atopy.87,88 Autoimmunity in DOCK8 deficiency has been reported to manifest as vasculitis, autoimmune hepatitis, or IPEX-syndrome-like disease. This evidence concerns the gene DOCK8 and hyperinsulinemic hypoglycemia, familial, 4.