CXCL4 functions via the chemokine receptor CXCR3,27 which is expressed by various cell types,46–48 including tumour cells.49,50 Since CXCL4 induced migration (Supplementary Fig. S4b), invasion (Supplementary Fig. S4c) and metastasis of 67NR cells (Fig. 4d–k), we hypothesised that CXCL4 might act through CXCR3 expressed on tumour cells but not on other cell types present within the primary TME. Here, PF4 is linked to neoplasm.