PF4 and neoplasm: From the myeloid lineage, platelets that originate from the cytoplasm of megakaryocytes are major cellular mediators of haemostasis and thrombosis and are important modulators of tumour progression and metastasis.26 When platelets are activated, they produce several factors, including CXCL4, also known as chemokine C–X–C motif ligand 4 or platelet factor 4 (PF4).27 The contribution of CXCL4 to metastasis has not been investigated.