Among the 20 genes differentially expressed in blood sampled within both 2 or 3 years prior to diagnosis in metastatic cases, F5, TLR5 and C19orf59 have been previously observed differently expressed in whole blood of non-small cell lung cancer (NSCLC) patients compared to controls44 in one study and SLC25A5 in another study of blood samples from NSCLC cases and controls45. Here, SLC25A5 is linked to non-small cell lung carcinoma.