This retrospective study confirmed several factors related to the death of COVID-19 patients receiving intensive care, including heart rate, leukocyte count, neutrophil count, lymphocyte count, NLR, platelet count, albumin level, urea nitrogen level, serum chloride level, myoglobin level, BNP level, D-dimer level, LDH level, CRP level, PCT level, PaO2/FiO2 level, and chest imaging severity, among which the level of PaO2/FiO2 was an independent risk factor. The gene discussed is MB; the disease is COVID-19.