RNF123 and brain disorder: With respect to brain tissue, rs2029591 is an eQTL for AMT, FAM212A, GPX1, NCKIPSD and RNF123. Of these five genes, there is literature to support a potential role in brain disorder for AMT, FAM212A and NCKIPSD. AMT forms part of the enzymatic system responsible for glycine cleavage in mitochondria37.