In human breast cancer SUM190-PT cells that express nectin-4 and nectin-1, nectin-4 trans-interacts with nectin-1 or nectin-4 and furthermore cis-interacts with integrin β4, promoting anchorage-independent survival through the SHP2-c-Src signaling in soft agar41. This evidence concerns the gene PTPN11 and breast carcinoma.