While all F2 females derived from the OID grand-paternal lineage (COxOID, OIDxCO, OIDxOID) showed higher mammary tumor growth with significantly larger tumors (Fig. 5a) when compared to COxCO, only OIDxOID females developed impaired insulin sensitivity as shown by higher glucose levels in ITT and AUC values (P = 0.007, P = 0.017, Fig. 5j,k). The gene discussed is INS; the disease is breast cancer.