In particular, we found that in the majority of COVID-19 patients, the SARS-CoV-2 antigen-specific Abs bound to FcγRIIIa-V158 and FcγRIIa-H131 soluble dimers at high levels, even at 1:800 plasma titrations, suggesting that besides potential neutralizing activity, alternative antibody-mediated activity such as ADCC and ADCP are likely to contribute to viral clearance18,19,28. This evidence concerns the gene FCGR3A and COVID-19.