It is plausible that upon infection with SARS-CoV-2, the elderly may preferentially induce skewed Ab responses targeting prior cross-reactive hCoV antigens and as observed in this study, COVID-19-positive elderly induced elevated IgG and IgA antibodies to the more cross-reactive antigens of SARS-CoV2 including S2 and NP, compared to children. This evidence concerns the gene CD79A and COVID-19.