Previous studies have identified somatic BRAF p.V600E mutations as drivers of two pathologically distinct pituitary tumours, namely the non-secreting benign pituitary tumour known as papillary craniopharyngioma (PCP)16,17, and more recently ACTH-secreting pituitary adenomas leading to Cushing’s disease18. This evidence concerns the gene POMC and benign neoplasm of pituitary gland.