To exclude the potential impact of neuronal SIRPα as well as the developmental change caused by early microglial SIRPα deletion, we have applied ADAPPswe, PSEN1dE9/SIRPα-cKO mice model (by tamoxifen induction, microglial SIRPα was specifically ablated at 2 months age) to investigate the role of microglial SIRPα deficiency on AD pathogenesis in adulthood (Fig. 7a). Here, SIRPA is linked to Alzheimer disease.