TET2 and obesity due to melanocortin 4 receptor deficiency: These variants were transcribed from four genes: CFAP6118, ESRRG (Estrogen-Related Receptor Gamma, important for type-1 muscle fiber development, estrogen signaling, and obesity susceptibility34,35), TET2 (Tet Methylcytosine Dioxygenase 2, involved in myogenic differentiation of skeletal myoblast cells and muscle age-related decline in mice36–38), and PLAG1 (Pleiomorphic Adenoma Gene 1, known to be more highly expressed in older humans16,39) (Fig. 6a and Supplementary Fig. 10).