These variants were transcribed from four genes: CFAP6118, ESRRG (Estrogen-Related Receptor Gamma, important for type-1 muscle fiber development, estrogen signaling, and obesity susceptibility34,35), TET2 (Tet Methylcytosine Dioxygenase 2, involved in myogenic differentiation of skeletal myoblast cells and muscle age-related decline in mice36–38), and PLAG1 (Pleiomorphic Adenoma Gene 1, known to be more highly expressed in older humans16,39) (Fig. 6a and Supplementary Fig. 10). This evidence concerns the gene PLAG1 and obesity due to melanocortin 4 receptor deficiency.