Mechanistically, RANK overexpression in CRC not only activated the canonical key downstream of RANK signaling, but also notably induced the Ca2+ oscillation dependent of phospholipase C-gamma (PLCγ)-mediated inositol-1,4,5-trisphosphate (IP3) receptor (IP3R) axis and stromal interaction molecule 1 (STIM1) to activate calcineurin/nuclear factor of activated T‐cells c1 (NFATC1)-tartrate-resistant acid phosphatase 5 (TRAP/ACP5) axis to promote metastasis. Here, ACP5 is linked to colorectal carcinoma.