HOXC6 and neoplasm: In the HT29 cell line, a similar result was observed that tumor cells were more sensitive to irinotecan (P < 0.01, t-test), 5-FU + irinotecan (P < 0.01, t-test) and 5-FU + irinotecan+oxaliplatin (P < 0.05, t-test) by knockdown of HOXC6 (Fig. 6B).