To further test the SENP1 induction by platinum drugs in vivo, we measured SENP1 protein levels in IGROV1 xenograft tumors by using immune histochemistry (IHC) in implanted immunodeficient nude mice that were treated with carboplatin at 20 mg/kg or 60 mg/kg after tumor was developed. The gene discussed is SENP1; the disease is neoplasm.