To test this hypothesis, we examined the expression level of SENP1 mRNA in six paired sensitive an resistant ovarian cancer cell lines, including SKOV3 WT, SKOV3 CR, IGROV1 WT, IGROV1 CR, A2780 WT, A2780 CR, PEO1, PEO4, PEO14, PEO23, OV90 WT and OV90 CR. The gene discussed is SENP1; the disease is ovarian cancer.