To explore whether RUNX2 binds to SENP1 promoter region in ovarian cancer cells, we performed ChIP assay and found that RUNX2 was enriched at promotor region of SENP1 but not at a negative region of SENP1 promotor, indicating that RUNX2 directly binds to SENP1 promotor in both IGROV1 CR and SKOV3 CR cells (Fig. 5E and F). Here, SENP1 is linked to ovarian cancer.