SENP1 and ovarian carcinoma: To explore whether RUNX2 binds to SENP1 promoter region in ovarian cancer cells, we performed ChIP assay and found that RUNX2 was enriched at promotor region of SENP1 but not at a negative region of SENP1 promotor, indicating that RUNX2 directly binds to SENP1 promotor in both IGROV1 CR and SKOV3 CR cells (Fig. 5E and F).