Therefore, we analyzed whether HIF1α is involved in regulation of LMP1 on BNIP3in LMP1-positive NPC cells with HIF1α inhibitor 2ME2 treatment, and the data showed that with the inhibition of HIF1α, BNIP3 mRNA and protein expression decreased accordingly (Fig. 5B, C). The gene discussed is BNIP3; the disease is nasopharyngeal carcinoma.