We thus propose a simple model (Fig. 7E) in which the LMP1-induced BNIP3 through ERK/HIF1α are crucial to the disruption of an interaction between Bcl-2 and Beclin1, thereby releasing the negative autophagic blockade, and further triggering the radioresistance of the NPC tumor. Here, HIF1A is linked to nasopharyngeal carcinoma.