After transient transfection with pGV141-LMP1-wt plasmids in CNE1,HNE2, and HK1 cells, the results indicated that LMP1 could induce BNIP3 and LC3II expression in NPC cells, suggesting LMP1 could induce autophagy related to BNIP3 (Fig. 2D, E). The gene discussed is BNIP3; the disease is nasopharyngeal carcinoma.