TP53 and cancer: GSEA results showed that the high-risk group was strongly associated with cancer-related pathways including mismatch repair (NES = 2.045, normalized P = 0.004, FDR q-val = 0.005), cell cycle (NES = 2.382, normalized P < 0.0001, FDR q-val < 0.0001), nucleotide excision repair (NES = 2.017, normalized P = 0.006, FDR q-val = 0.006), p53 signaling pathway (NES = 2.069, normalized P < 0.0001, FDR q-val = 0.004), and pathways in cancer (NES = 1.585, normalized P = 0.021, FDR q-val = 0.109) (Figure 3D).