The characteristic of ccRCC is the loss of chromosome 3p, including mutations of genes encoding von Hippel-Lindau tumor suppressor (VHL), polybromo-1 (PBRM1), BRCA1-associated protein 1 (BAP1) and SET domain containing 2 (SETD2) [6]. This evidence concerns the gene SETD2 and nonpapillary renal cell carcinoma.