TRA2B and obesity due to melanocortin 4 receptor deficiency: For example, the obese and metabolic impact on the reduced expression of transformer 2β homolog (TRA2B/SFRS10) which belongs to the SR-like protein family of splicing factors was observed in liver and muscle tissues from obese patients; the SFRS10 down-regulation can alter the splicing pattern of LPIN1 to induce lipid accumulation, which therefore causes aberrant metabolic phenotypes and obesity [112].