Moreover, other cohort studies revealed quantitative AS changes in the transcriptome in WAT where gene splicing profiles displayed abnormal features in the contexts of nutritional changes, obesity, and dysmetabolism [102], including the genes of Lamin A/C (LMNA) [103], cannabinoid type I receptor (CB1R) [104], and T cell-specific transcription factor 7-like 2 (TCF7L2) [105]. Here, LMNA is linked to obesity due to melanocortin 4 receptor deficiency.