For example, a novel genetic variation with a disruption in canonical splice-site acceptor of the IGF2 gene among the Mexican population has been identified to function as a protective factor to reduce the type 2 diabetes risk at ∼ 20% through repressing splicing between the exons 1 and 2 and reducing the expression of IGF2 isoforms [119]. Here, IGF2 is linked to type 2 diabetes mellitus.