More than 100 genes were upregulated in the amygdala of the 3-month-old AD mice (Fig. 5a; Supplementary Table 5), including Tnfαip8l3, Sstr1, Sstr4, Chrm5 and Aldh1a3 (Figs. 4g; 5a, c). This evidence concerns the gene TIPE3 and Alzheimer disease.