Overall, APP/PSEN1-Tg animals seem not to present a complete anosmia, although it seems that they display a loss of discrimination between odours, so this possible hyposmia together with working memory (Additional file 1: Figure S1E and F) [83, 84] impairments could explain the indiscriminate investigation that transgenic mice display. The gene discussed is APP; the disease is Anosmia.