The APP/PSEN1-Tg transgenic mice spent lower percentage of time in open arms than non-transgenic at both 3 (t30 = 2.30, p = 0.0286; Fig. 1a) and 6 months old (t26 = 2.419, p = 0.0229; Fig. 1d), whereas no differences were found in the total number of arm entries (t30 = 0.65, p = 0.520, Fig. 1b and t26 = 1.21, p = 0.236, Fig. 1e), indicating that APP/PSEN1-Tg animals displayed higher level of anxiety-like behaviours without locomotor impairments. The gene discussed is PSEN1; the disease is Anxiety.