APOE and Alzheimer disease: Moreover, it has recently been described the implication of triggering receptor expressed on myeloid cells (TREM)-APOE pathway related with microglial β-amyloid plaque clearance [17] and neuroinflammatory responses in neurodegenerative diseases, such as AD [12], with a dysregulation of Clec7 and Itgax transcripts related to inflammation and apoptotic processes, crucial components in the early-onset AD [18].