We conducted a sex-specific analysis to further evaluate whether this anxiety phenotype was limited to male GrnR493X/R493X mice and found that male knockin mice spent significantly less time in the central zone than Grn+/+ males, while female Grn+/+/GrnR493X/R493X mice spent similar amounts of time in each region (Fig. 9b, c). The gene discussed is GRN; the disease is Anxiety.