This approach identified several proteins (SPARC-related modular calcium-binding protein 1, brain acid soluble protein 1, neuromodulin, pyruvate kinase PKM, thymosin beta-10, 14-3-3 protein zeta/delta, and fructose-bisphosphate aldolase A) in strong accordance with recent studies of the AD CSF proteome [24, 65]. This evidence concerns the gene SMOC1 and Alzheimer disease.