In the meta-analysis of differential gene expression across brain tissues in AMP-AD, TREM2, KANSL1, RAB10, MS4A6A, and RIN3 were found to be significantly upregulated in AD compared to control individuals, while TAOK2 was significantly downregulated (reported associations were FDR-significant, Table S7). This evidence concerns the gene MS4A6A and Alzheimer disease.