Recently, an observation study involving CGM for 281 adult type 2 diabetes outpatients aged 40–75 years, including 181 patients aged 65–70 years, revealed that low HbA1c level and use of hypoglycemic agents related to hypoglycemia including sulfonylureas, glinides and insulin were associated with high TBR [11]. This evidence concerns the gene INS and type 2 diabetes mellitus.