In the process of establishing a mouse hepatoma model, we found that the expression of HBP1 was gradually reduced, while AFP expression increased gradually (Fig. S4), suggesting that the function of HBP1 is gradually suppressed in the process of hepatitis-cirrhosis-hepatoma, and the deregulation of the HBP1-AFP axis contributes to hepatoma progression. The gene discussed is AFP; the disease is Cirrhosis.