They have been designed to target the CD38, such as the daratumumab (Darzalex, Janssen Biotech, Inc. Horsham, PA), the daratumumab/hyaluronidase (Darzalex Faspro, Janssen Biotech, Inc. Horsham, PA), and the isatuximab (Sarclisa, Sanofi-Aventis, Bridgewater, NJ), or they are CD30-directed Antibody Drug conjugate (ADC), meaning that they consist of a targeted therapy monoclonal antibody and an antineoplastic (chemotherapy) agent that work together to destroy cancer cells, such as the brentuximab vedotin (Adcetris, Seattle Genetics, Inc. Bothell, WA). Here, CD38 is linked to cancer.