AKT1 and melanoma: In Melanoma cases, it has been reported that apigenin activates the cleaved caspase-3, PARP expression sites, downregulate Twist1, MMP-2/9, VEGF, p-mTOR, ERK1/2 proteins and p-AKT, deactivate FAK/ERK1/2 pathways and silenced STAT3 phosphorylation [22, 23].