Further correlation analysis presented that 33 of 47 (i.e., PDCD1, CTLA4, etc.,) immune check blockade-associated genes expression levels were significantly upregulated in patients with high-risk (Fig. 5h), suggesting ALL prognostic signature might act as nonnegligible and unfavorable factor in immunotherapy operating. Here, PDCD1 is linked to acute lymphoblastic leukemia.