Furthermore, we detected the apoptosis and epithelial-mesenchymal transition (EMT) associated proteins in osteosarcoma cells via western blot, and the results showed that Mφ-Exos significantly inhibited the expression of apoptosis protein cleaved-PARP, Bax, and EMT marker E-cadherin, but promoted the expression of anti-apoptosis protein Bcl-2, and EMT marker N-cadherin. The gene discussed is CDH2; the disease is osteosarcoma.