And some studies have reported that Smad4 is an important transcriptional regulator of TGF-β pathway and the loss of Smad4 function is related to the occurrence and evolution of a variety of solid tumors, especially related to the metastasis of pancreatic cancer, ovarian cancer, breast cancer, and intestinal cancer [19–22]. This evidence concerns the gene SMAD4 and familial pancreatic carcinoma.