Abbreviations: GAM, general additive model; HOMA-IR, homeostatic model assessment-insulin resistance; CI, confidence interval; FEV1, forced expiratory volume in 1 s; FVC, forced vital capacity; BMI, body mass index; BP, blood pressure; HDL, high density lipoprotein; eGFR, estimated glomerular filtration rate; WBC, white blood cell; CRP, C-reactive protein. Here, CRP is linked to Insulin resistance.