Analysis of protein expression of human leukocyte antigen-A (HLA-A), apoptosis antigen 1 (Fas), c-c chemokine receptor type 5 (CCR5), Fas ligand (FasL) and HLA-E in tumor tissues demonstrated that in the tissues of mice with poor miR-222 expression, a significant increase in Fas protein expression and a significant decline in HLA-A, CCR5, FasL, and HLA-E protein expression were observed (Fig. 4e). This evidence concerns the gene HLA-E and neoplasm.