IGF2R and primary biliary cholangitis: PBC patients demonstrated significantly increased liver-specific DNA compared to controls as measured by all 3 genes, IGF2R: (median (IQR)) 281.93 (126.24–597.61) Geq/ml versus 112.85 (66.71–184.19) Geq/ml, p = 0.0001 (Fig. 3a), ITIH4: 441.79 (256.40–837.79) Geq/ml versus 256.83 (122.99–399.69) Geq/ml, p = 0.0004 (Fig. 3b), and VTN: 334.73 (149.76–879.57) Geq/ml versus 133.13 (72.03–202.66), p < 0.0001 (Fig. 3c).