IGF2R and primary biliary cholangitis: These levels were also significantly increased in PBC patients with late-stage compared to early-stage disease when measured by IGF2R: (median (IQR)) 453.79 (221.47–862.67) Geq/ml versus 180.20 (95.97–355.83) Geq/ml, p = 0.0068 (Fig. 3a) and VTN: 822.01 (248.81–1359.55) Geq/ml versus 198.29 (114.34–595.37), p = 0.0024 Geq/ml (Fig. 3c).