The LASSO COX regression analysis of 18 significant genes was implemented, and 9 genes (AGT, ANGPT1, SERPINE1, ANGPT2, PVT1, PROCR, KIT, PLAUR and CAV1) were screened out which could be the independent prognostic predictor in GC (Fig. 4a, b). This evidence concerns the gene ANGPT2 and gastric cancer.