To test the causality of this association and its neural substrate, they injected an AAV5 expressing NTF3 (AAV5-CMV-NTF3) into the dorsal amygdala and found decreases in anxiety-like behavior with associated changes in metabolism throughout the brain’s distributed anxiety-related circuitry, including the bed nucleus of the stria terminalis (Fox et al., 2019). The gene discussed is NTF3; the disease is Anxiety.