ACE and cancer: One study has suggested that using ARBs increases the risk of cancer,4 whereas two subsequent meta-analyses showed no such association.11, 12 Another meta-analysis of randomised controlled trials found no evidence linking any drug class with the incidence of any cancer,12 but an increased risk of cancer with the use of angiotensin-converting enzyme inhibitors (ACEIs) in combination with ARBs could not be ruled out.