This study revealed a genetic machinery that is equally important for both types of infection modes, since a similar detrimental impact on the nodulation process was observed in the nfr5, symrk, ccamk, cyclops, nin, nsp1, nsp2 epr3, cbs, and vpy1 mutants whether M. loti or IRBG74 were used as inoculum in Lotus (Figure 8). The gene discussed is NIN; the disease is infection.