We found that D1D2CAR did not mediate HIV-1 infection (Fig 1B), did not react to IL-16 stimulation (Fig 4B and 4C) and had similar anti-HIV-1 activity as compared to CD4CAR both in vitro and in vivo (Figs 2B, 2C and 4A). The gene discussed is IL16; the disease is HIV-1 infection.