Importantly, whereas flagellin was not required for the role of Dnmt3b in Pseudomonas induced CXCL1 expression in BEAS-2B cells in vitro, Dnmt3bfl/flCc10Cre mice only demonstrated an enhanced innate immune response after infection with WT PAK but not after infection with flagellin deficient PAKflic. The gene discussed is DNMT3B; the disease is infection.