In contrast to Dnmt3bfl/flCc10Cre mice, Dnmt3bfl/flSpCcre mice did not differ from littermate control mice with regard to local release of CXCL1 (Fig 6A), neutrophil recruitment (Fig 6B), BALF MPO levels (Fig 6C) or bacterial clearance (Fig 6D) after infection with wild-type PAK via the airways. Here, MPO is linked to infection.