Thereafter, we analyzed the conditions underwhich erosive arthritis occurred at a high rate, focusing on the elevation in thelevels of CD8+ peripheral blood lymphocytes (PBLs) after EBV infection.We speculate that EBV infections contribute to some of the unclear factorsinfluencing RA pathogenesis, and we believe that these EBV-infected hu-NOG miceconstitute an erosive arthritis model, potentially yielding insights into RApathogenesis. Here, CD8A is linked to Arthritis.