Furthermore, this model can help confirm thetherapeutic effects of anti-human RANKL antibody or cathepsin K inhibitor.However, a mouse model displaying activated human osteoclasts is extremelyvaluable and is potentially applicable in studies on the association between EBVinfections and RA and with human bone metabolism using mouse models such asthose of osteoporosis. This evidence concerns the gene CTSK and osteoporosis.