TP53 and cancer: The GWAS hits highlighted an enrichment of genes involved in cancer pathways (cell cycle, p-value = 9.28 × 10−3; cellular senescence, p-value = 0.013; bladder cancer, p-value = 0.049; aging, p-value = 0.0024; signaling pathways regulating pluripotency of stem cells, p-value = 0.0066; TP53 network, p-value = 0.03) and lipid metabolism (regulation of lipid metabolism by peroxisome proliferator-activated receptor alpha [PPARalpha], p-value = 0.016; response to leptin, p-value = 0.0066).