In the CFA5 locus, nine of the top ten variants of CFA5 that were found to be associated with the risk of developing HS were imputed variants; they were localized between positions 30,483,338 and 30,496,048 that overlap the SPNS3 gene (S3 Table and S4 Fig). The gene discussed is SPNS3; the disease is histiocytic sarcoma.