Pathway enrichment analysis revealed differentially expressed pCRCSC-related miRNAs to be enriched in I-kappa B kinase/NF-kappa B signaling, signal transduction by p53 class mediator, Ras signaling pathway, actin cytoskeleton regulation, cGMP-PKG signaling pathway, and spliceosome pathways, which are known to correlate with the malignant phenotype of cancer cells [31–33]. Here, CHUK is linked to cancer.