KDR and preeclampsia: The adverse vascular and renal effects occurring during VEGFI have been termed a preeclampsia-like syndrome as these resemble the hallmarks of the severe pregnancy complication preeclampsia.121 Preeclampsia is characterized by hypertension, proteinuria, and increased plasma levels of sFlt-1 (soluble fms-like tyrosine kinase-1), a soluble VEGFR.