In this study, we collected tissue samples from breast cancer patients with or without brain metastasis and found that, compared with that in the non‐metastasis group, the expression of tissue lncRNA‐CCRR, CSF lncRNA‐CCRR, tissue CX43 mRNA and tissue CX43 protein was all evidently up‐regulated in metastasis patients, while patients with brain metastasis showed even higher lncRNA‐CCRR expression compared with patients with no brain metastasis. This evidence concerns the gene GJA1 and breast cancer.