Fibroblasts from a CLN5 patient were reprogrammed via expression of SOX2, OCT3/4, KLF4 and MYC to generate the CLN5Y392* (New RefSeq sequence: Y343*) iPSC line, the predominant mutation in CLN5 Batten disease. The gene discussed is CLN5; the disease is juvenile neuronal ceroid lipofuscinosis.