However, in the future, more work needs to be done for exploring the effect and mechanism of the activation of proNGF/p75NTR and JNK pathways on inhibiting HD-induced neuronal apoptosis in vivo, as well as on whether inhibiting proNGF/p75NTR and JNK pathways might be used as the therapeutic targets to treat the HD-induced neuronal apoptosis in humans. This evidence concerns the gene MAPK8 and Huntington disease.