This analysis identified 3 broad categories of factors: (1) transcription factors that were previously reported to be involved in cancer-associated EMT progression, such as NFKB1,39STAT3,40RELA,41JUN,42 and HIF1A;43 (2) transcription factors, most of which were downregulated, that are known to be involved in RPE differentiation, such as OTX2,44BCL6,45 and ZFP36,46 and (3) kinases that may modulate the RPE-EMT response, such as AKT1,47MAPK1,48IKBKB,49 and MAP2K1 (MEK1).50 This evidence concerns the gene HIF1A and cancer.