The second most enriched pathway arising from the IPA analysis was hepatic fibrosis/hepatic stellate cell activation, with enriched genes COL8A2, MMP2, LAMA1, IGFBP5, PDGF, MYH8, TGFBR2, and SERPINE1. Although, as the name implies, this pathway includes molecules related to response to liver damage, the molecules identified in these pathways also potentially modulate the tissue fibrosis that develops in the retina as part of the pathology associated with neovascular AMD.33 This evidence concerns the gene IGFBP5 and Hepatic fibrosis.