Similar effects were observed for infection of P1/7-SLY on nlrp3−/− mice, it induced significantly decreased level of IL-1β, IL-17A, and IFN-γ comparing to the infection on nlrp3+/+ mice (Figure 5A), while the bacterial burden in the blood did not significantly decrease at the given time point (Figure 5B). This evidence concerns the gene NLRP3 and infection.