NLRP3 and infection: However, no significant difference was observed on the survival rate and clinical symptoms of infection by P1/7 strain and P1/7-SLY in nlrp3−/− mice, while P1/7-SLY but not P1/7 strain caused development of STSLS in nlrp3+/+ mice (Figure 5 and Supplementary Figure S2), these also supported our previous conclusion that hyperactivation of NLRP3 was essential for STSLS development [11].