Notably, ΔNp63 is expressed in the epithelium of the affected organ in other types of type 2 inflammation‐related allergic disease, including bronchial asthma, allergic rhinitis or conjunctivitis, and eosinophilic esophagitis.21, 43, 44, 45 In particular, esophageal squamous epithelium exposed to IL‐13 behaved in an opposite manner to ΔNp63‐knockdown keratinocytes in our experiment for some genes expression including SERPINB3, SERPINB4, or DAPL1.46 Here, SERPINB3 is linked to eosinophilic esophagitis.