Endemic Kaposi's sarcoma is a common disease of children in sub‐Saharan Africa and was documented before the introduction of HIV. Like other herpes viruses, HHV‐8 has the ability to escape the host's immune response during initial infection, during sustained latency and during reactivation. The host uses two levels of defence to counter microbial infection; the innate immune system and the adaptive immune system HHV‐8 has developed multiple molecular mechanisms to evade host immunity. MAVS has been observed to participate211. Here, MAVS is linked to Kaposi's sarcoma.