The HSV viral cycle can be divided into different phases including146 (i) entry phase; (ii) expression of viral genes, the glycoproteins and other virion components involved in the development of the infection, including UL41, which induces inhibition of host protein synthesis, destroying most of the mRNAs, allowing HSV to fully take over the protein synthesis machinery and increase efficiency of virus production and UL13 protein kinase, whose absence blocks infection. Here, ART4 is linked to infection.