58 Luminmycin A and other natural products belonging to the luminmycin class were successfully isolated following heterologous expression of the same gene cluster, using E. coli as host.59,60 Recently, luminmycin A was successfully synthesized in the laboratory by Servatius et al.61 Luminmycin A inhibits the constitutive proteasome (CP) as well as the immunoproteasome (IP), (ChT-L IC50: 0.039 ± 0.002 μM (CP), 0.016 ± 0.006 μM (IP); T-L 0.026 ± 0.008 μM (CP), 0.017 ± 0.0016 μM (IP)).53 The natural product also exhibits cytotoxic activity against human carcinoma HCT-116 cells (IC50: 91.8 nM). The gene discussed is CP; the disease is carcinoma.